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INSTITUTE FOR RESEARCH IN MOLECULAR MEDICINE

Research Products and Patents

Commercialized Products

Six diagnostic kits have been commercialized at national and international markets and more are in the pipeline. Rapid diagnostics commercialized include antibody detection to Salmonella Typhi using dot EIA via TYPHIDOT (to detect for specific lgM and lgG), TYPHIDOT-M (to detect for specific lgM), TYPHirapid (a immunochromatography test for rapid detection of lgM to Salmonella Typhi), Brugia Rapid to detect brugian filariasis caused by Brugia malayi and Brugia timori and panLF Rapid to detect both brugian and bancroftian filariasis. The latest innovations are diagnostic kits that do not require "cold chain transport", thus making important diagnostics available and accessible in many low resource countries. The inventions of INFORMM are patented and resultant diagnostic kits of INFORMM are licensed to commercial partners who take over the marketing and support for the products. Commercialization is important to enable these kits be made available to the end users for diagnosis, while income generation from the commercial activities are important for the sustainability of research activities and product.

List of products

  • TYPHIDOT
  • TYPHIDOT-M
  • TYPHIrapid – Discontinued
  • BRUGIArapidTM
  • WBrapidTM – Discontinued
  • PanLFrapid

Patents Granted

1. DNA sequence encoding the specific antigen of Salmonella typhi.  Ismail A., M. Ravichandran, Ong, K.H. and Kader, Z.A.

  • Malaysian Patent: MY-126769-A (2006)
  • South African Patent: 2001/1406 (2001)
  • Indonesian Patent: ID 0016938 (2006)
  • Australia Patent: 783201 (2005)
  • Bangladesh Patent: 1003617 (2002)
  • Pakistan Patent: 137538 (2000)
  • Korean Patent  No.: 425884 (2003)
  • African Regional Intellectual Property Office (ARIPO) App. No.: AP/P/01/02026(2004)
  • Philippines Patent  No.: 1-8791/DELNP/ 2008 (2009)
  • Vietnamese Patent Application No.: 1-2001-00184  (2010)

2. Filarial Parasite Polypeptides and Sequences, Gene Sequences and Uses Thereof. Rahmah, N.

  • Indonesia Patent Application No.: P20001121 (2009)
  • Malaysian Patent Application No.: PI 9905731 (2007)
  • Indonesia Patent Application No. 101/MUM-WTO/2000 (953/MUM/2000)](2000)
  • India Patent Application No.: 954/MUM/2000 [101/MUM-WTO/2000(953/MUM/2000)]  (2011)

3. A Disposable Multiplex Polymerase Chain Reaction (PCR) Chip and Device.  Asma Ismail, Sugumar Dharmalingam and Kong, Lingxue

  • Singapore KASS International Application No.200905002-2  (2010)

4. Oligonucleotides Used For Detecting Vibrio Cholera  And Method of Detecting Therewith. Asma Ismail, Lalitha Pattabiraman, Manickam Ravichandran, Zainul Fadziruddin Zainuddin

  • Malaysia: Kass International  (2007)

5. Recombinant Antigen For Detection of Toxocariasis. Rahmah Noordin, Suharni Mohamad

  • German Patent Application No.: 112009004267.8 (2013)
  • United Kingdom Patent Application No.: GB2479279 (2013)
  • Japan Patent Application No.: 5614409 (2014)
  • USA Patent Application No.: 8,962,259 (2015)

6. Diagnosis of Entamoeba Histolytica. Rahmah Noordin, Tan Zi Ning, Nurulhasanah Othman, Lim Boon Huat, Zeehaida Mohamed, Wong Weng Kin

  • South Africa Patent Application No.: 2014/00469 (2015)

7. (R)-6-(Dimethylamino) - 4,4-Diphenylheptan-3-one. Asaraf Ali Mohamed Kassim, Rusli Ismail, Tan Soo Choon

  • US Patent Application No.: 9,212,128 B2 (2015)

8. Method For Rapid Detection of Lymphatic Filariasis. Rahmah Noordin and Rohana Abdul Rahman

  • Vietnam Patent Application No.: 15710 (2016)
  • Technology Licencing to Reszon Diagnostics International Sdn Bhd

9. A Diagnostic Kit For Detection of Lymphatic Filariasis. Rahmah Noordin and Rohana Abdul Rahman

  • Vietnam Patent Application No.: 15845 (2016)
  • Technology Licencing to Reszon Diagnostics International Sdn Bhd

10. Serum Infection Markers for Diagnosis of Toxoplasmosis. Rahmah Noordin, Emelia Osman, Zeehaida Mohamed, Chen Yeng

  • Malaysia Patent Application No.: MY-152751-A (2014)

11. Curcumin Compounds with Superior Structural Stability and Processes for Their Preparation Thereof. Mohamed Ashraf Ali, Noor Shahida Ajmi, Yeong Keng Yoong, Rusli Ismail, Tan Soo Choon

  • Malaysia Patent Application No.: MY-153032-A (2014)

12. Pyrrolothiazole Containing Curcumin Compounds. Mohamed Ashraf Ali, Yeong Keng Yoon, Ang Chee Wei, Rusli Ismail, Tan Soo Choon

  • Malaysia Patent Application No.: MY-153034-A (2014)

13. A Method for Preparing an Immunogen and a Use Thereof. Mohamed Ashraf Ali, Lei Mei Jin, Rusli Ismail, Tan Soo Choon, Sharif Mahsufi Mansor, Surash Ramanathan

  • Malaysia Patent Application No.: MY-157066-A (2016)
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